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10 Best sinus medicines of 2025

Explore up to 28% off
  • Best Choice

    1

    Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets
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    Mucinex

    Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

    21% Off
    9.8
    Exceptional
    More info
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  • Value for Money

    2

    Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps
    Vicks

    Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps

    9.7
    Exceptional
    Our Rating
    More info

  • 3

    Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
    Tylenol

    Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

    28% Off
    9.4
    Excellent
    More info

  • 4

    Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
    Tylenol

    Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

    15% Off
    9.1
    Excellent
    Our Rating
    More info

  • 5

    Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, Acetaminophen, Pain Reliever, Fever Reducer, Phenylephrine HCl, Decongestant, Sinus Congestion Relief; 24 ct; Pack of 1
    Sudafed

    Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, Acetaminophen, Pain Reliever, Fever Reducer, Phenylephrine HCl, Decongestant, Sinus Congestion Relief; 24 ct; Pack of 1

    15% Off
    9.0
    Excellent
    Our Rating
    More info
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  • 6

    Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps
    Vicks

    Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

    8.9
    Very Good
    More info

  • 7

    Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets
    Advil

    Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets

    8.7
    Very Good
    Our Rating
    More info

  • 8

    Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct
    Sudafed

    Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct

    22% Off
    8.6
    Very Good
    Our Rating
    More info

  • 9

    Sudafed PE Day and Night Sinus Pressure & Congestion Tablets, 20 Count
    Sudafed

    Sudafed PE Day and Night Sinus Pressure & Congestion Tablets, 20 Count

    20% Off
    8.5
    Good
    Our Rating
    More info

  • 10

    Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct
    Benadryl

    Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct

    19% Off
    8.3
    Good
    More info