Updated: 05 Feb 2025

10 Best acetaminophens of 2025

Explore up to 41% Off

Updated: 05 Feb 2025

#1

Best Choice
HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | Non-Habit Forming (365 Count (Pack of 1))

9.8

HealthA2Z

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Why we love it

Quickly relieves pain and aids sleep.

Non-habit forming sleep aid.

No added gluten or aspirin.

Main highlights

Fast Acting Pain Relief and Sleep Aid
500 mg Acetaminophen and 25 mg Diphenhydramine provide quick pain relief and help you fall asleep.

Ideal for Nighttime Use
Perfect for adults needing pain relief and better sleep at night.

Value for Money
Customers appreciate the cost-effectiveness without compromising quality.
#2

Best Value
HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

9.7

HealthA2Z
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#3
HealthA2Z® Children's Chewable Pain Relief | Acetaminophen 160mg | 60 Chewable Tablets | Grape Flavor Chewables | Aspirin & Ibuprofen Free

9.6

HealthA2Z

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Main highlights

The chewables come in a grape flavor that is gentle on the tummy and can be used by children ages 2 to 11 years old

HealthA2Z Children's Pain Relief Acetaminophen 160mg, 60 Chewable Tablets

Each chewable tablet contains 160 milligrams of the pain reliever and fever reducer acetaminophen to temporarily reduce fever and help relieve minor aches and pains due to the common cold, flu, sore throat, headache, and toothache.
#4
Member's Mark 500mg Extra Strength Acetaminophen MegaSize 2Pack (600 Count Each) 7hm2Dcs

9.5

MEMBER´S MARK
#5
Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

9.3

Amazon Basic Care

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Why we love it

Fast relief for pain and fever.

Ideal for those avoiding aspirin or ibuprofen.

Child-resistant cap ensures safety.

Main highlights

Rapid Pain Relief and Fever Reduction
Contains 500 mg of acetaminophen for quick relief of pain and fever.

Ideal for Headaches and Muscle Aches
Perfect for headaches, muscle aches, arthritis, and menstrual pain.

Highly Praised for Effectiveness
Customers appreciate its quick and reliable pain relief.
#6
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)

9.2

Amazon Basic Care

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Why we love it

Affordable alternative to name brands.

Effective pain and fever relief.

Large quantity for extended use.

Main highlights

Effective Pain Relief
Contains 500 mg of acetaminophen, comparable to Tylenol, for pain and fever relief.

Versatile Use Cases
Ideal for minor aches, headaches, arthritis, and reducing fever.

Value for Money
Praised for being cost-effective and as effective as name brands.
#7
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)

9.0

Amazon Basic Care

-41%

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Why we love it

Affordable and effective pain relief.

Easy-to-swallow caplets.

Comparable to brand-name Tylenol.

Main highlights

Fast-Acting Pain Relief
Contains acetaminophen 500 mg for quick relief from minor aches and fever.

Versatile Use Cases
Ideal for relieving headaches, backaches, menstrual cramps, and minor arthritis pain.

Highly Praised Affordability
Customers appreciate its cost-effectiveness and performance comparable to brand-name products.

-41%
#8
Timely Acetaminophen 500mg - 500 Caplets - Extra Strength Pain Relief - Compared to the active ingredient in Extra Strength Tylenol - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis

8.9

TIME-CAP LABS, INC.

-17%

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Why we love it

Effective pain relief for various conditions.

Affordable alternative to branded options.

Easy-to-open bottle for arthritic hands.

Main highlights

Comprehensive Pain Relief
Acetaminophen relieves minor aches from headaches, backaches, toothaches, arthritis, and menstrual cramps.

Ideal for Family Use
500 caplets ensure ample supply for family medicine cabinets.

Highly Praised Accessibility
The bottle is easy to open, suitable for arthritic hands.

-17%
#9
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

8.7

Amazon Basic Care

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Why we love it

Effective for arthritis and minor pain relief.

Aspirin-free and gluten-free formula.

Extended-release for longer-lasting relief.

Main highlights

Extended-Release Pain Relief
Provides 650 mg acetaminophen for up to 8-hour relief.

Ideal for Arthritis and Aches
Perfect for arthritis, backache, cramps, and other minor pains.

Value and Effectiveness
Praised for great value and effective pain relief.
#10
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

8.6

TIME-CAP LABS, INC.

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Why we love it

Affordable alternative to branded options.

Effective for various pain relief needs.

Extended release for prolonged relief.

Main highlights

Effective Pain Relief
Provides relief for headaches, backaches, toothaches, arthritis, and menstrual cramps.

Ideal for Family Use
400 caplets ensure long-term relief for the whole family.

Cost-Effective Solution
Praised for offering similar effectiveness to branded versions at a lower cost.

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Our top pick

#1

HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | Non-Habit Forming (365 Count (Pack of 1))
HealthA2Z Extra Strength Pain Relief PM combines 500 mg of Acetaminophen, a proven pain reliever, with 25 mg of Diphenhydramine, a gentle sleep aid, to offer effective nighttime relief. This dual-action formula is designed to alleviate muscle, joint, headache, and arthritis pain while helping you fall asleep and stay asleep. Ideal for adults and children over 12 years, this non-habit forming product provides a safe option for those seeking relief from minor aches and pains without the inclusion of aspirin or gluten. Its cost-effectiveness is frequently praised by users, making it a reliable and budget-friendly choice. With a simple dosage of two caplets at bedtime, HealthA2Z ensures you wake up refreshed and pain-free, ready to tackle the day ahead. Its practical design and proven effectiveness make it a standout option for nighttime pain relief and sleep support.

10 Best acetaminophens of 2025

HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | Non-Habit Forming (365 Count (Pack of 1))

9.8

Why we love it

Main highlights

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

9.7

HealthA2Z® Children's Chewable Pain Relief | Acetaminophen 160mg | 60 Chewable Tablets | Grape Flavor Chewables | Aspirin & Ibuprofen Free

9.6

Main highlights

Member's Mark 500mg Extra Strength Acetaminophen MegaSize 2Pack (600 Count Each) 7hm2Dcs

9.5

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

9.3

Why we love it

Main highlights

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)

9.2

Why we love it

Main highlights

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)

9.0

Why we love it

Main highlights

Timely Acetaminophen 500mg - 500 Caplets - Extra Strength Pain Relief - Compared to the active ingredient in Extra Strength Tylenol - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis

8.9

Why we love it

Main highlights

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

8.7

Why we love it

Main highlights

TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

8.6

Why we love it

Main highlights

Similar products on Amazon

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

Amazon Basic Care Pain Relief, Acetaminophen Tablets 325 mg, Regular Strength, Pain Reliever and Fever Reducer, 100 Count (Packaging may vary)

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)

Amazon Basic Care Pain Relief, Acetaminophen Tablets 325 mg, Regular Strength, Pain Reliever and Fever Reducer, 100 Count (Packaging may vary)

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)

Our top pick

HealthA2Z® Extra Strength Pain Relief PM| Acetaminophen 500mg | Diphenhydramine 25mg | Pain Reliever & Nighttime Sleep Aid | Non-Habit Forming (365 Count (Pack of 1))

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